Name: Genistein-4,6,2',3',5',6'-d6
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA STI 088194
Chemical name:	Genistein-4,6,2',3',5',6'-d6
CAS Number:	197657-74-2
Category:	enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors
Synonyms:	5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d6; Baichanin A-d6; Bonistein-d6; 4',5,7-Trihydroxyisoflavone-d6; GeniVida-d6; Genisteol-d6; Prunetol-d6; Sophoricol-d6;
Molecular form:	C₁₅H₄D₆O₅
Appearance:	Light Yellow Solid
Mol. Weight:	276.27
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Labelled Genistein. Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.

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