| Catalogue number: | PA STI 088194 |
| Chemical name: | Genistein-4,6,2',3',5',6'-d6 |
CAS Number: |
197657-74-2 |
| Category: | enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors |
| Synonyms: | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d6; Baichanin A-d6; Bonistein-d6; 4',5,7-Trihydroxyisoflavone-d6; GeniVida-d6; Genisteol-d6; Prunetol-d6; Sophoricol-d6; |
| Molecular form: | C15H4D6O5 |
| Appearance: | Light Yellow Solid |
| Mol. Weight: | 276.27 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Labelled Genistein. Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. |
Genistein-4,6,2',3',5',6'-d6
Genistein-4,6,2',3',5',6'-d6
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