(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

In House Impurity
Print | Download pdf
Stock Status : <%stockStatus%>

<%deliveryStatus%>

Catalogue number: PA 05 0721003
Chemical name: (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

CAS Number:

193146-26-8
Category: chiral standards,pharmaceutical standards,impurities,metabolites,Fine Chemicals
Synonyms:

(3S,6R,7S,8S,12Z,15S,16E)-3,7-Bis((tert-butyldimethylsilyl)oxy)-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid;
Molecular form: C39H71NO6SSi2
Appearance: Oil
Mol. Weight: 738.23
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

193146-26-8
| Sample COA MSDS

Enquire for (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

I accept terms and conditions

Order Product

Related Products

189453-10-9

Epothilone D
210690-85-0

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
189453-35-8

(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
152044-54-7

Epothilone B - API Standards

193146-51-9

(3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-Tetrakis-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one

EVENTS

Search by Keywords – Buy 193146-26-8 | Purchase 193146-26-8 | Order 193146-26-8 | Enquire 193146-26-8 | Price of 193146-26-8 | 193146-26-8 Cost | 193146-26-8 Supplier | 193146-26-8 Distributor | 193146-26-8 Manufacturer | 193146-26-8 Exporter

Tools

Calculators

Normality Dilution Mass molarity
Periodic Table- Pharmaffiliates

Periodic Table

Ask A Scientist-Pharmaffiliates

Ask a Scientist
General Help

General Help

cart bucket

×
Proceed

wishlist

×
Proceed