Tipifarnib - API Standards

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Catalogue number: PA 20 3170000
Chemical name: Tipifarnib

CAS Number:

192185-72-1
Category: impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:

R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; Zarnestra;
Molecular form: C27H22Cl2N4O
Appearance: Off-White to Pale Beige Solid
Mol. Weight: 489.4
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin.

Tipifarnib

192185-72-1
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