Name: Genistein-2',3',5',6'-d4 (Major)
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA STI 088196
Chemical name:	Genistein-2',3',5',6'-d4 (Major)
CAS Number:	187960-08-3
Category:	enzyme inhibitors,tyrosine kinase inhibitors,stable isotopes
Synonyms:	Baichanin A-d4; Bonistein-d4; 4',5,7-Trihydroxyisoflavone-d4; GeniVida-d4; Genisteol-d4; Prunetol-d4; Sophoricol-d4; 5,7-Dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-;
Molecular form:	C₁₅H₆D₄O₅
Appearance:	Yellow Solid
Mol. Weight:	274.26
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

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Genistein-2',3',5',6'-d4 (Major)

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