ENMD 547-d8

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Catalogue number:	PA STI 037030
Chemical name:	ENMD 547-d8
CAS Number:	1795025-33-0
Category:	miscellaneous compounds,stable isotopes
Synonyms:	6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine-d8 Monohydrobromide;
Molecular form:	C₁₅H₂₂D₈BrN₃O₂
Appearance:	N/A
Mol. Weight:	372.37
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Labelled ENMD 547, a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.