Name: WYE 354-d3
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA STI 087450
Chemical name:	WYE 354-d3
CAS Number:	1794791-66-4
Category:	stable isotopes,miscellaneous compounds
Synonyms:	4-[6-[4-[[(Methoxy-d3)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester; WYE-354-d3;
Molecular form:	C₂₄H₂₆D₃N₇O₅
Appearance:	NA
Mol. Weight:	498.55
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

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WYE 354-d3

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