Name: 1-(2-Iodoethyl)-2-octylbenzene
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 06 0961007
Chemical name:	1-(2-Iodoethyl)-2-octylbenzene
CAS Number:	162358-96-5
Category:	intermediates,impurities,metabolites,pharmaceutical standards,Fine Chemicals
Synonyms:	2-Octylphenethyl iodide;
Molecular form:	C₁₆H₂₅I
Appearance:	NA
Mol. Weight:	344.28
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	1-(2-Iodoethyl)-2-octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

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1-(2-Iodoethyl)-2-octylbenzene

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