Name: Abacavir Sulfate - Impurity D (Freebase)
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA 01 01041
Chemical name:	[(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol
CAS Number:	1443421-67-7
Alternate CAS Number:	783292-37-5 (Relative Stereochemistry)
Similar Products:	NA(DiHCl Salt);NA(HCl Salt)
Category:	Fine Chemicals,pharmaceutical standards,intermediates
Synonyms:	(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; trans-Abacavir; {(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol (USP);
Molecular form:	C₁₄H₁₈N₆O
Appearance:	NA
Mol. Weight:	286.34
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	(1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

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Abacavir Sulfate - Impurity D (Freebase)

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