Name: Zavegepant Hydrochloride - API Standards
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 26 0480000
Chemical name:	Zavegepant Hydrochloride
CAS Number:	1414976-20-7
Similar Products:	1337918-83-8(freebase)
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide Hydrochloride;
Molecular form:	C₃₆H₄₇ClN₈O₃
Appearance:	NA
Mol. Weight:	675.28
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist.5 CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways. CGRP receptors are expressed in the central and peripheral nervous system; however, CGRP does not cross the blood-brain barrier, suggesting that it acts on peripheral nerves. In migraine, CGRP innervates pain-producing meningeal blood vessels and is released by trigeminal nerve stimulation. Since they inhibit these mechanisms and desensitize neuronal circuits, the use of CGRP receptor antagonists is beneficial in the treatment of migraine

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