Name: Abacavir Sulfate - Impurity A (Freebase)
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA 01 01010
Chemical name:	[(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopent-2-en-1-yl]methanol
CAS Number:	136470-79-6
Similar Products:	935777-88-1(sulfate salt)
Category:	intermediates,antiviral agents,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides
Synonyms:	ent-Abacavir; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol; (1R,4S)-Abacavir;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol;
Molecular form:	C₁₄H₁₈N₆O
Appearance:	Off-White to Pale Yellow Solid
Mol. Weight:	286.33
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

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Abacavir Sulfate - Impurity A (Freebase)

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