Name: Tamoxifen-13C6
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA STI 080830
Chemical name:	Tamoxifen-13C6
CAS Number:	1346606-38-9
Category:	aromatics,stable isotopes,pharmaceutical standards,intermediates,Fine Chemicals,protein kinase inhibitors and activators
Synonyms:	(Z)-2-[4-[1-(phenyl-13C6)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine; ICI 47699-13C6; Mammaton-13C6; Novaldex-13C6; Tamoxifen-13C6; Z-Tamoxifen-13C6;trans-Tamoxifen-13C6;
Molecular form:	C₂₀₁₃C₆H₂₉NO
Appearance:	NA
Mol. Weight:	377.47
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

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