Name: Lapaquistat-d9 Acetate
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA STI 056080
Chemical name:	Lapaquistat-d9 Acetate
CAS Number:	1292841-28-1
Category:	amines,chiral standards,heterocycles,enzyme inhibitors,stable isotopes,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid-d9; (3R-trans)-1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid-d9; TAK 475-d9;
Molecular form:	C₃₃H₃₂D₉ClN₂O₉
Appearance:	NA
Mol. Weight:	654.20
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	A novel labelled squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels. Antiarteriosclerotics.

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Lapaquistat-d9 Acetate

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