Name: Encorafenib - API Standards
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 05 1940000
Chemical name:	Encorafenib
CAS Number:	1269440-17-6
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	Methyl (S)-(1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate; Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester; Braftovi;
Molecular form:	C₂₂H₂₇ClFN₇O₄S
Appearance:	NA
Mol. Weight:	540.01
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Encorafenib is a kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations. Encorafenib, also known as BRAFTOVI, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations Label. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion. Mutations in this gene, most frequently the V600E mutation, are the most commonly identified cancer-causing mutations in melanoma, and have been isolated in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of the lung 6.

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