Isopropyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate

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Catalogue number: PA 18 1081041
Chemical name: Isopropyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate

CAS Number:

1256490-31-9
Category: impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:

L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester; N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl Ester;
Molecular form: C18H21N2O7P
Appearance: Pale Yellow Oil
Mol. Weight: 408.35
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: N-​[(S)​-​(4-​Nitrophenoxy)​phenoxy-​2,​3,​4,​5,​6-​d5-​phosphinyl]​-​L-​Alanine-d5 1-​Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5, an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Isopropyl ((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate

1256490-31-9
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