Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant

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Catalogue number:	PA 28 0071005
Chemical name:	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant
CAS Number:	1185503-48-3
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	(2S,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine;aprepitant M2 Metabolite (1R, 2S, 3R)-Isomer;
Molecular form:	C₂₀H₁₈F₇NO₂
Appearance:	NA
Mol. Weight:	437.36
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant is an impurity of Aprepitant ; a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

1185503-48-3

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