Aminopterin-α-hyrazide

In House Impurity

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Catalogue number:	PA 13 0281009
Chemical name:	Aminopterin-α-hyrazide
CAS Number:	118359-33-4
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	N5-Amino-N2-(4-((2,4-diaminopteridin-6-yl)(methyl)amino)benzoyl)-L-glutamine;
Molecular form:	C₁₉H₂₂N₁₀O₄
Appearance:	NA
Mol. Weight:	454.45
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Aminopterin-α-hyrazide, is derivative of Aminopterin (A628850), which is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.