Combretastatin A4

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Catalogue number:	PA 27 0017662
Chemical name:	Combretastatin A4
CAS Number:	117048-59-6
Category:	miscellaneous compounds
Synonyms:	(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol;
Molecular form:	C₁₈H₂₀O₅
Appearance:	Off-White to Pale Beige Solid
Mol. Weight:	316.35
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.