2,3,4,5-Tetrahydro-7-methoxy-4-(methyl-d3)-1,4-benzothiazepine

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Catalogue number:	PA STI 082110
Chemical name:	2,3,4,5-Tetrahydro-7-methoxy-4-(methyl-d3)-1,4-benzothiazepine
CAS Number:	1167435-22-4
Category:	stable isotopes,miscellaneous compounds
Synonyms:	S 107-d3;
Molecular form:	C₁₁H₁₂D₃NOS
Appearance:	NA
Mol. Weight:	212.33
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	t is a labelled benzothiazepine derivative that binds the RyR1 channel and enhances the binding affinity of Calstabin-1. By preventing the depletion of Calstabin-1 from the RyR1 complex, S 107 slows muscle fatique and reduces muscle damage in exercised mice. In a murine model of Duchenne muscular dystrophy, S 107 reduces biochemical and histological evidence of the muscle damage associated with muscular dystrophy, improves muscle function, and increases exercise performance.