IWR-1-endo

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Catalogue number:	PA 27 0020585
Chemical name:	IWR-1
CAS Number:	1127442-82-3
Category:	miscellaneous compounds
Synonyms:	Rel-4-((3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide;
Molecular form:	C₂₅H₁₉N₃O₃
Appearance:	NA
Mol. Weight:	409.45
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.