Name: Entrectinib - API Standards
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 05 1630000
Chemical name:	Entrectinib
CAS Number:	1108743-60-7
Category:	pharmaceutical standards,impurities,intermediates,metabolites,Fine Chemicals
Synonyms:	N-(5-(3,5-Difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide;
Molecular form:	C₃₁H₃₄F₂N₆O₂
Appearance:	NA
Mol. Weight:	560.65
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kises. PXDX-101 has been well tolerated in patients with advanced solid tumors. PXDX-101 is currently in clinical trials, and is being developed by Ignyta.

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Entrectinib - API Standards

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