Name: Kifunensine
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA 27 0023736
Chemical name:	Kifunensine
CAS Number:	109944-15-2
Category:	miscellaneous compounds
Synonyms:	(5R,6R,7S,8R,8aS)-6,7,8-Trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine;
Molecular form:	C₈H₁₂N₂O₆
Appearance:	White to Off-White Solid
Mol. Weight:	232.19
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis._x000B__x000B_When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.

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