SAR131675

Stock Status : <%stockStatus%>

<%deliveryStatus%>

Catalogue number:	PA 27 0020985
Chemical name:	SAR131675
CAS Number:	1092538-80-1
Category:	miscellaneous compounds
Synonyms:	2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;
Molecular form:	C₁₈H₂₂N₄O₄
Appearance:	White to Pale Yellow Solid
Mol. Weight:	358.4
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.