Name: Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 27 0024549
Chemical name:	Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate
CAS Number:	109244-58-8
Category:	miscellaneous compounds
Synonyms:	Benzoic acid, 2-(3,6-diamino-9H-xanthen-9-yl)-, methyl ester; Dihydrorhodamine 123;
Molecular form:	C₂₁H₁₈N₂O₃
Appearance:	NA
Mol. Weight:	346.39
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Dihydrorhodamine 123 (DHR 123) is a cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite. It is not fluorescent until oxidized by ROS to the highly fluorescent product Rhodamine 123. Neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DHR, rather, these ROS are thought to combine with other cellular components such as cytochrome c oxidase or Fe2+ in order to oxidize DHR 123 to its fluorescent derivative Rhodamine 123. Formation of Rhodamine 123 can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 500 and 536 nm, respectively, or by absorbance spectroscopy at 500 nm (ε = 78,800 M-1cm-1).Dyes and metabolites.

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Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate

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