| Catalogue number: | PA 12 1540000 |
| Chemical name: | Linopirdine |
CAS Number: |
105431-72-9 |
| Category: | impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals |
| Synonyms: | 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one; 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one; |
| Molecular form: | C26H21N3O |
| Appearance: | NA |
| Mol. Weight: | 391.47 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4 micromolar disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons. |
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