Rebastinib

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Catalogue number:	PA 27 0016379
Chemical name:	Rebastinib
CAS Number:	1020172-07-9
Category:	miscellaneous compounds
Synonyms:	4-(4-(3-(3-(tert-butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; 4-[4-[(5-tert-Butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;
Molecular form:	C₃₀H₂₈FN₇O₃
Appearance:	Off-White Solid
Mol. Weight:	553.60
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Rebastinib shows the selectivity for growth inhibition of Bcr-Abl-positive cells by its marked inhibition of CML cell lines compared to non-CML leukemia lines. Rebastinib is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.